"Skin, An Ideal Target for Gene Therapy."

According to the author's abstract of an article published in Presse Medicale, "Keratinocytes, fibroblasts and tumour cells of skin cancers can be the target of two different strategies based on gene therapy: direct in vivo gene transfer or in vitro transfer after harvesting skin cells. For in vivo transfer, the problem is to develop techniques which limit effective gene transfer to skin cells without dissemination. For in vitro transfer, the keratinocytes, for example, are isolated and cultured to produce an epithelium comparable to the body surface which is then grafted as has been done for burns for more than a decade. Fibroblasts can also be biopsied and cultured. Transfer systems...

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