Cancer Gene Therapy

Radiation Beam Used To Time and Target Gene Therapy

Published in Gene Therapy Weekly, August 14th, 1995

Researchers at the University of Chicago Medical Center, Illinois, have devised a way to combine gene therapy with radiation therapy to attack cancer cells - a powerful therapeutic one-two punch with no more side effects than standard radiation therapy.

This innovative approach is reported in the August 1995 issue of Nature Medicine.

The researchers linked the gene for tumor necrosis factor-alpha (TNF-(alpha))-a natural substance which can directly kill tumor cells as well as make them more sensitive to radiation - with the "on-off switch" from another gene, known as Egr-1. The Egr-1 switch is flipped on by exposure to radiation.

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Source: Gene Therapy Weekly (1995-08-14)

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