"New Strategies for Mucosal Immunization Using Recombinant Poliovirus Vaccines."

According to an abstract submitted by the authors to the 8th International Congress of Mucosal Immunology, held July 17-20, 1995, in San Diego, California, "Poliovirus is attractive for the development of vectors for a mucosal vaccine because the virus is transmitted via a fecal oral route. The attenuated strains of poliovirus have been used to produce an effective vaccine that is routinely given orally to infants and generates both systemic and mucosal immunity. To explore poliovirus as a vector, we have constructed genomes which contain the complete HIV or SIV gag or env genes substituted for the poliovirus capsids genes. We have developed a complementation system to supply the...

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