Cancer Gene Therapy
"HER-2/neu-Targeting Gene Therapy - A Review."
Published in Gene Therapy Weekly, August 14th, 1995
According to the authors' abstract of an article published in Gene, "The HER-2/neu (also named c-erbB-2) oncogene is known to be overexpressed in many human cancers, including breast, ovarian, lung, gastric and oral cancers. In animal models, HER-2/neu overexpression was shown to enhance malignancy and metastasis phenotypes. Repression of HER-2/neu overexpression suppresses the malignant phenotypes of HER-2/neu-overexpressing cancer cells, suggesting that HER-2/neu may serve as an excellent target for developing anti-cancer agents. We have previously shown that the adenovirus-5 (Ad5) E1a gene products and the SV40 large T antigen (large T) inhibit transcription of the HER-2/neu promoter...
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Source: Gene Therapy Weekly (1995-08-14)
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