Genetics

DNA Circles Produce Seven Times RNA as Conventional Methods

Published in Gene Therapy Weekly, August 28th, 1995

By using very small synthetic circular DNA molecules as a substrate, a University of Rochester, New York, chemist has tricked the enzyme that makes RNA into producing many more copies of RNA than it does using conventional methods.

The work, dubbed "rolling circle RNA synthesis," should be useful for scientists who need many strands of an identical piece of RNA for laboratory experiments or even, someday, gene therapy.

"It's a little like a mimeograph machine," says Eric T. Rool, associate professor of chemistry. "The RNA polymerase goes around and around the molecule, producing multiple copies joined end-to-end." The work is described in the July...

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Source: Gene Therapy Weekly (1995-08-28)

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