Published in Gene Therapy Weekly, August 28th, 1995
Because gene transfer to blood vessels in vivo usually requires that blood flow be interrupted, gene transduction to cerebral blood vessels in vivo has not been accomplished, noted Hiroaki Ooboshi, University of Iowa College of Medicine, Iowa City, Iowa, and colleagues.
With the aim of transducing genes to cerebral blood vessels, Ooboshi et al. injected replication-deficient adenovirus into cerebrospinal fluid of rats ("Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue,"...
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