Oncogenesis

Alterations of Messenger RNA Can Cause Cancer

Published in Gene Therapy Weekly, September 11th, 1995

In an unexpected finding, scientists at the Gladstone Institute of Cardiovascular Disease, University of California San Francisco (UCSF) General Hospital, have reported for the first time that the production of a protein that can modify messenger RNA (mRNA) can cause cancer.

Until now, it had been thought that oncogenes were activated solely by mutations to the DNA which forms the genes. In a paper published in the August 29, 1995, issue of the Proceedings of the National Academy of Sciences, the Gladstone researchers report that abberant modifications of mRNA caused large tumors in the livers of transgenic mice and rabbits. The study opens up the possibility that...

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Source: Gene Therapy Weekly (1995-09-11)

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