Gene Targeting
Method Allows for In Vivo Gene Inactivation
Published in Gene Therapy Weekly, September 25th, 1995
Current processes for gene inactivation involve gene deletion in the germlines of specially bred mice. An inherent drawback of this approach is that the animal is born (if the gene is not necessary for development) with this deletion and the effects can only be compared to mice without this deletion. The changes that this gene deletion could make in the ontogenous development of the animal, and/or its ability to react to certain stimuli might not be easily discernible or compensated for through the stages of development.
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Source: Gene Therapy Weekly (1995-09-25)
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