"Experimental Gene Therapy of Cancer using Tumor Cells Engineered to Secrete Interleukin-13."

According to the authors' abstract of an article published in European Journal of Immunology, "Cytokines locally delivered to the site of a tumor boost both specific and nonspecific host anti-tumor defenses. Interleukin (IL)-13 is a recently described cytokine produced by a mouse type 2 helper T lymphocytes. The aim of this study was to evaluate the inhibition of tumor growth induced by IL-13 delivered locally within or around transplanted tumor cells in mice. We observed that local administration of IL-13 at the site of transplanted tumor cells in vivo had potent inhibitory effects on growth of both immunogenic (P815 mastocytoma, H-2(d)) or nonimmunogenic (3LL lung carcinoma, H-2(b))...

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