Published in Gene Therapy Weekly, October 16th, 1995
Oligonucleotides can be used to control viral genome expression. Two methods can be used in order to specifically inhibit viral replication with synthetic oligonucleotides: 1) the oligonucleotide can be designed to interact with proteins involved in the biosynthetic process (the sense or 'decoy' approach); or 2) the oligonucleotide can be designed to bind to a complimentary sequence of the viral genome, which is used as a template by the viral polymerase - e.g., retroviral reverse transcriptases (the antisense approach).
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