"Design, Biochemical, Biophysical and Biological Properties of Cooperative Antisense Oligonucleotides."

According to the authors' abstract of an article published in Nucleic Acids Research, "Short oligonucleotides that can bind to adjacent sites on target mRNA sequences are designed and evaluated for their binding affinity and biological activity. Sequence-specific binding of short tandem oligonucleotides is compared with a full-length single oligonucleotide (21mer) that binds to the same target sequence. Two short oligonucleotides that bind without a base separation between their binding sites on the target bind cooperatively, while oligonucleotides that have a one or two base separation between the binding oligonucleotides do not. The binding affinity of the tandem oligonucleotides is...

Want to see the full article?

• Purchase this article for only $3.00