Cancer Gene Therapy (Immunology)

Host Immunosuppression Increases Gene Therapy Efficacy

Published in Gene Therapy Weekly, November 20th, 1995

Researchers show that the host's immune response against adenovirally transduced cells limits the therapeutic efficacy of gene transduction.

In general terms, enhanced immune reactions against tumors is therapeutically useful. However, research with adenoviral vectors has shown that host immune responses against the vector limits the efficacy and persistence of gene expression.

Ashraf A. Elshami et al. questioned the effect of the host immune response against adenoviruses on cancer gene therapy with HSVtk gene delivery by an adenovirus vector followed by ganciclovir treatment in an animal model ("The Role of Immunosuppression in the Efficacy...

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Source: Gene Therapy Weekly (1995-11-20)

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