Published in Gene Therapy Weekly, November 20th, 1995
As HIV predominantly infects cells of the hematopoietic system, stem cells are good potential targets for the introduction of foreign anti-HIV genes. Ex vivo transduction, and then reimplantation of the genetically modified stem cells into HIV infected patients could allow the repopulation of the host with mature CD4+ cell populations expressing novel molecules that interfere with viral replication and slow progression into AIDS.
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