"Biodistribution of Monoclonal Antibodies: Scale-Up from Mouse to Human using a Physiologically Based Pharmacokinetic Model."

According to the authors' abstract of an article published in Cancer Research, "The efficacy of a novel diagnostic or therapeutic agent depends on its selective localization in a target tissue. Biodistribution studies are expensive and difficult to carry out in humans, but such data can be obtained easily in rodents. We have developed a physiologically based pharmacokinetic model for scaling up data from mice to humans, the first such model for genetically engineered macromolecules that bind to their targets in vivo, such as mAbs. The mathematical model uses physiological parameters including organ volumes, blood flow rates, and vascular permeabilities; the compartments (organs) are...

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