Antisense Technology (Collagenase Inhibition)
"Inhibition of Collagenase Type I Expression by Psoralen Antisense Oligonucleotides in Dermal Fibroblasts."
Published in Gene Therapy Weekly, December 4th, 1995
According to the authors' abstract of an article published in FASEB Journal, "Type I collagenase plays an important role in both tumor metastasis and the remodeling of connective tissue in normal human skin, during wound healing, for example, and may participate in the pathophysiology of some dermatological diseases such as skin cancer and a chronic blistering disease, recessive dystrophic epidermolysis bullosa. In an effort specifically to inhibit collagenase expression, we have designed phosphorothioate antisense oligonucleotides, linked at the 5' ends with photoreactive 4'-(hydroxyethoxymethyl)-4,5',8-trimethylpsoralen (HMT), and directed them against the 5' end of the collagenase...
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Source: Gene Therapy Weekly (1995-12-04)
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