Published in Gene Therapy Weekly, December 11th, 1995
One of the benefits of adenoviral-mediated gene transfection is its ability to transfect nonactive cells with great efficiency. One of its drawbacks is that the gene expression is transient, rarely lasting more than a few weeks.
One reason for the transient expression is that the host induces a cellular immune response against the transduced cells. In addition, a secondary genetic transfection via the same adenoviral vector is not possible due to host production of neutralizing antibodies against the adenovirus.
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