"Cancer Therapy Through Direct Administration of gamma-IFN Retrovector."

According to an abstract submitted by the authors to the 4th International Conference on Gene Therapy of Cancer, held November 9-11, 1995, in San Diego, California, "Several murine models demonstrate that a decrease in tumorigenicity of tumor cells is associated with an increase in the level of MHC class I expression. gamma-IFN is one cytokine that can up-regulate MHC class I expression. Two approaches to increase the immunogenicity of tumor cells are being evaluated: ex vivo transduction of tumor cell lines and direct in vivo administration of gamma-IFN Retrovector into murine tumors. Tumor cells transduced ex vivo with murine gamma-IFN Retrovector are rendered non-tumorigenic in vivo....

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