Cancer Gene Therapy
"Hepatoma Cell-Specific Expression of a Retrovirally Transferred Gene Is Achieved by Alpha-Fetoprotein But Not Insulinlike Growth Factor II Regulatory Sequences."
Published in Gene Therapy Weekly, February 5th, 1996
According to the authors' abstract of an article published in Hepatology, "To target gene expression to malignant hepatic cells, we have constructed recombinant retroviral vectors containing a reporter gene encoding nuclear beta-galactosidase (nls-LacZ) under transcriptional control of regulatory sequences from the rat Lu-fetoprotein (AFP) or human insulinlike growth factor II (IGFII) genes, The AFP and IGFII P3 promoters activate transcription during fetal development and are often reactivated in hepatocellular carcinoma (HCC). Infection of several cultured cell types with the retroviral vector containing the IGFII P3 sequence resulted in expression of the reporter gene in all cell lines...
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Source: Gene Therapy Weekly (1996-02-05)
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