Cancer Gene Therapy
"Therapeutic Antitumor Response after Immunization with a Recombinant Adenovirus Encoding a Model Tumor-Associated Antigen."
Published in Gene Therapy Weekly, February 5th, 1996
According to the authors' abstract of an article published in Journal of Immunology, "Recombinant adenovirus (rAd), deleted of critical genes that enable viral replication and replaced with genes encoding heterologous proteins, has been shown to be a safe and effective vector in gene therapy studies. To evaluate a potential role for rAd as an immunogen, we used two different replication-defective type 2 rAds encoding the model Ag, beta-galactosidase (beta-gal). To determine whether rAd elicited the kind of immune responses therapeutic in an anti-tumor setting, the beta-gal-expressing adenocarcinoma, CT26.CL25, was used, Splenocytes from BALB/c mice immunized with 1x107...
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Source: Gene Therapy Weekly (1996-02-05)
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