Vascular Disease

Adenoviral Vectors Damage Normal Arteries: Use Cautioned

Published in Gene Therapy Weekly, March 4th, 1996

Study addresses the deleterious effect of adenovirus vectors alone on the arterial phenotype of normal arteries.

Replication defective adenovirus vectors have become the vector of choice for a majority of researchers studying vascular disease and its potential therapies. Adenoviruses have an efficient rate of arterial gene transfer in nondividing cells, they are easy to prepare and produce a high-titer virus concentration.

Potential disadvantages of adenovirus as an arterial gene transfer vector include the induction of both humoral and cellular immune responses by the virus. Researchers have attempted to bypass this problem by rendering the virus...

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Source: Gene Therapy Weekly (1996-03-04)

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