Conference Coverage (NCVDG)

New Approach to Genetic Immunization

Published in Gene Therapy Weekly, March 11th, 1996

A powerful new approach to genetic immunization promises to create highly effective vaccines for AIDS, tuberculosis, and other diseases.

The resulting vaccines have the potential for both prophylactic and therapeutic applications.

The method is called expression library cloning. This involves systematically breaking down the genome of a pathogen into segments that can be manipulated until the most immunogenic epitopes are found.

"The problem with DNA vaccines is that, unlike live vaccines, the [immunogenic ] antigen must be defined," said researcher Stephen A. Johnston of the University of Texas Southwestern Medical Center,...

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Source: Gene Therapy Weekly (1996-03-11)

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