Published in Gene Therapy Weekly, March 11th, 1996
Many attempts have been made to induce cellular immunity against tumors by using modified tumor cells as anti-cancer vaccines. Unfortunately, even highly antigenic tumors are not completely rejected by the host's immune system with these approaches.
Subsequently, it has been determined that effective priming of the immune system to a particular tumor antigen requires costimulatory signals which can be provided by specialized antigen-presenting cells (APCs), and not the tumor itself. Costimulatory molecules include those in the B7 family and the cytokine family. Protocols which...
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