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Drug Resistance
"P-Glycoprotein Confers Methotrexate Resistance in 3T6 Cells with Deficient Carrier-Mediated Methotrexate Uptake."
March 18th, 1996
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that enter the cell by passive diffusion through the lipid bilayer. Pgp-expressing multidrug-resistant cell lines are not usually cross-resistant to a hydrophilic antifolate methotrexate (MTX). MTX enters cells primarily through a folate carrier, but passive diffusion becomes the primary mode of MTX uptake in carrier-deficient cells. To test if a deficiency in MTX carrier would allow Pgp to confer resistance to MTX, a MTX...
Source: Gene Therapy Weekly (1996-03-18)
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