Antisense Technology (HIV)
Nicked Dumbbell Oligonucleotides Shows Increased Nuclease Resistance
Published in Gene Therapy Weekly, March 25th, 1996
The therapeutic use of oligonucleotides as sense and antisense agents holds much promise as well as posing many problems. Antisense oligonucleotides have been used to inhibit viral as well as cellular gene expression. Unfortunately, they easily undergo nucleolytic degradation and are sensitive to exonucleases.
Phosphorothioate oligonucleotides are primarily degraded at the 3'-end. Several stabilization methods have been attempted, including chemical substitutes at the 3'-hydroxyl groups and creating oligonucleotides containing a hairpin loop...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (1996-03-25)
More Articles from Gene Therapy Weekly
- Conference Coverage (NCVDG)
Rhinovirus/HIV Chimeras Used to Define HIV Antigens - Conference Coverage (NCVDG)
Heterosexual AIDS Epidemic Could Expand in U.S., Europe - Cancer Gene Therapy (Gliomas)
Adenovirus-Mediated p53 Gene Transfer Inhibits Brain Tumor Growth - Conference Coverage (NCVDG)
Targeted Lymph Node Immunization Protects Against Rectal Challenge - Crohn's Disease
Gene May Be Linked to Intestinal Disorder - Gene Discovery
Identification of Two Genes in Pathogenesis of Asthma Announced - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
