Genetics (HBV)

Genomes Associated with Fulminant Disease are Unique

Published in Gene Therapy Weekly, April 1st, 1996

Hepatitis B virus genomes associated with epidemic fatal fulminant hepatitis have numerous unique mutations, located mainly in the polymerase and pre-core gene, according to a report from Japan.

Epidemic fulminant hepatitis B in multiple contacts of a single hepatitis B virus strain provides a unique opportunity to investigate the genetic basis of fulminant hepatitis B, since host factors, including immune responses or human leukocyte antigen (HLA) haplotypes, can be excluded for consideration in this setting.

Researcher Yasuhio Asahina and colleagues sought to determine the complete nucleotide sequences of hepatitis B virus (HBV) genomes obtained...

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Source: Gene Therapy Weekly (1996-04-01)

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