Published in Gene Therapy Weekly, April 8th, 1996
Suicide gene therapy using the adenoviral-mediated herpes simplex thymidine kinase (Ad.tk) gene transfection method followed by ganciclovir (GCV) treatment shows promise as a primary treatment for cancers and as well as a secondary therapy for destruction of residual cells. Its use has also been documented in the purging of autologous donor materials of cancer cells before retransplantation.
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