Published in Gene Therapy Weekly, April 8th, 1996
Many methods and techniques have been developed for in vivo gene transfer. Viral-mediated gene transfer has its drawbacks due to complications of the viral vector. Although plasmid-mediated gene transfer is economical, easy to use, and avoids many of the problems of virus-mediated gene transfer, it is not as efficient or site specific as it could be.
Recently, electrical permeabilization of cell membranes has been developed for the purpose of achieving highly efficient in vitro gene and/or drug...
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