"Partial Protection Against Plasmodium yoelii by a DNA Vaccine Encoding the C-Terminus of MSP-1."

According to an abstract submitted by the authors to the 7th Malaria Meeting of the British Society for Parasitology, held September 19-21, 1995, in London, United Kingdom, "Three DNA vaccines encoding the PYC2 fragment (aa165s-1757) of P. yoeliiMSP1 were prepared in the nkCMVintpolyli vector: 1) MSP-1 alone [(T-)MSP-1], 2) MSP-1 with a mammalian signal peptide [S(T-)MSP-1], and 3) MSP-1 with a signal peptide and promiscuous T helper epitopes from tetanus toxin [S(T+)MSP-1]. A fourth construct prepared in the pDIP vector contained a signal peptide and 82 aa of human IL-2 (pDIPMSP-1). BALB/c mice were immunized i.e. 3 times at 3 week intervals with 100 119 of DNA. Mice in a...

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