"Augmentation of Antitumor Immunity using Genetically M-CSF-Expressing L1210 Cells."

According to the authors' abstract of an article published in Experimental Hematology, "Macrophage colony-stimulating factor (M-CSF) enhances tumoricidal activities of macrophages. We transduced human M-CSF cDNA into the mouse lymphoid cell line, L1210, and examined the antitumor effect of the locally expressed M-CSF. Mice injected with the M-CSF-producing subline showed improved survival in comparison with the mock-transfected cell line or parental cell line plus M-CSF administration (20 (mu)g/kg for 3 days) at inoculated cell numbers of 10² or 5x10³. The survival rate at 50 days after injection of 10⁶ high M-CSF-expressing cells was 80%, significantly...

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