"A Vaccine Trial Against Pre-Erythrocytic Stages of Plasmodium falciparum In Chimpanzees: Correlation Between Protective Efficacy after Challenge and T-Cell Activation Elicited by a PreDASH

According to an abstract submitted by the authors to the 7th Malaria Meeting of the British Society for Parasitology, held September 19-21, 1995, in London, United Kingdom, "We have used synthetic peptides and recombinant proteins corresponding to four different pre-erythrocytic stage antigens of P. falciparum (LSA-1, LSA-3, SALSA & STARP), combined with a novel adjuvant, to immunize a group of chimpanzees. Cellular immunological assessments were carried out before, during and after a challenge infection with live sporozoites of P. falciparum and correlations sought between immune responses to the immunizing antigens and putative protection determined through parasitological...

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