Immunology

New Data Support Danger Model of Immunity

Published in Gene Therapy Weekly, April 29th, 1996

New data support a rejection of the self/non-self theory of immunity.

The self/non-self theory - the mainstay of immunologic theory for the past 75 years - assumes that the immune system establishes its criteria for what must be tolerated as self during the early stages of its development.

The classic experiments of P.B. Medawar et al., conducted in the early 1950s, apparently confirmed this hypothesis that neonatal lymphocytes are susceptible to induction of tolerance during this unique period. Medawar et al. showed that rodents injected at birth with hematopoietic cells from a genetically heterogenous donor later tolerated transplants from the...

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Source: Gene Therapy Weekly (1996-04-29)

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