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Recombinant Vaccinia Virus: Effective Vector for Cancer Vaccines

Published in Gene Therapy Weekly, May 13th, 1996

Autologous tumor cells transfected with granulocyte macrophage-colony stimulating factor (GM-CSF) via a recombinant vaccinia virus vector have potential use as cancer vaccines.

Having utilized a murine model for in vivo studies, Sunil K. Chatterjee presented data at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C., which suggested that the use of recombinant vaccinia viruses to transfect cancer cells with GM-CSF have a place in cancer gene therapy.

"The advantages of this system include its ability to treat almost any type of cancer," remarked Chatterjee. "It can be used by either...

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