Published in Gene Therapy Weekly, May 13th, 1996
It has been proposed that viral DNA sequences can either act in cis to modify host gene expression or encode viral proteins that may interfere with normal cellular functions either directly or indirectly. A potential mechanism for the neoplastic transformation of hepatocytes by HBV is the inactivation of cellular proteins by viral proteins.
"We have tried to determine the mechanisms behind the HBV-X protein so that we can understand why it is an oncoprotein," stated Li Bin Jia et al. at...
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