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New Breast/Prostate Cancer Antigen Prepares for Vaccine Trial

Published in Gene Therapy Weekly, May 13th, 1996

Globo H covalently linked with QS-21 is being prepared for testing in breast cancer patients.

Globo H is a breast cancer associated carbohydrate antigen which was initially defined by the murine monoclonal antibody MBr1. G. Ragupathi of the Memorial Sloan-Kettering Cancer Center noted at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, DC, that the protein for Globo H was very difficult to synthesize initially. But now that a process has been developed, it can readily be linked with conjugates to create an anticancer vaccine.

"This is a new antigen, people are not familiar with it yet,"...

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