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IL-12 Immunotherapy for Bladder Cancer: 100% Effective in Animal Model

Published in Gene Therapy Weekly, May 20th, 1996

Adenoviral-mediated interleukin 12 (IL-12) administered locally effectively cures bladder cancer in 100 percent of the animals treated.

In previous research, L. Chen et al. from Harvard Medical School had shown that systemic administration of IL-12 could cure a percentage of mice burdened with the poorly immunogenic MB49 bladder cancer at the maximally tolerated dose. The cured mice were also capable of resisting rechallenge to the parental tumor in an IL-12 dose-dependent manner.

Building on these earlier experiments, colleague Stephen K. Clinton presented conclusions from a recent study at the 87th Annual Meeting of the American Association for...

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