Conference Coverage (AACR)

Gene Therapy Enhances Cancer Cells Chemosensitization

Published in Gene Therapy Weekly, May 20th, 1996

A novel gene therapy approach targets and sensitizes cancer cells to subsequent treatment with chemotherapeutic agents.

Numerous institutions have investigated suicide gene therapy using herpes simplex thymidine kinase gene transduction followed by ganciclovir treatment. Mark Barnes and colleagues from the University of Alabama took a different approach and explored the ability of a single chain antibody (sFv) to down regulate an oncogene thereby rendering it susceptible to subsequent chemotherapy.

Barnes presented study results using sFv directed against erbB2 in an ovarian tumor cell lines to enhance its cytotoxicity against subsequent treatment...

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Source: Gene Therapy Weekly (1996-05-20)

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