Conference Coverage (AACR)

Restoring Tumor Suppressor Genes: Gene Therapy for Prostate Cancer

Published in Gene Therapy Weekly, May 20th, 1996

Adenoviral restoration of tumor suppressor gene function in prostate cancer cells is therapeutically effective in a pre-clinical study.

Previous work by Akinobu Gotoh and colleagues has demonstrated that restoration of p53 tumor suppressor function via delivery by an adenoviral vector successfully depressed the growth of both androgen-dependent (AD) and androgen-independent (AI) human prostate tumors in vivo. At the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C., Gotoh presented results from in vitro and in vivo studies of restoration of p16, p53 and p21 tumor suppressor genes...

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Source: Gene Therapy Weekly (1996-05-20)

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