Antisense Technology
"Somatostatin Antisense Oligodeoxynucleotide-Mediated Stimulation of Lymphocyte Proliferation in Culture."
Published in Gene Therapy Weekly, June 3rd, 1996
According to the authors' abstract of an article published in Endocrinology, "We have previously shown that somatostatin (SRIF) is synthesized in B and T lymphocytes of rat spleen and thymus and released into the medium of cultured lymphocytes. To determine the role of SRIF in the control of lymphocyte proliferation, the expression of SRIF in normal lymphocytes was inhibited using a 3'-terminal phosphorethioate-modified antisense oligonucleotide complementary to a sequence that includes the translation start site of the rat SRIF messenger RNA. Spleens were obtained from adult male rats, and their lymphocytes were cultured for 24 or 72 h to measure SRIF content and cell proliferation,...
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Source: Gene Therapy Weekly (1996-06-03)
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