Cancer Gene Therapy
"Antitumor Effects of Granulocyte-Macrophage Colony-Stimulating Factor Production by Melanoma Cells."
Published in Gene Therapy Weekly, June 3rd, 1996
According to the authors' abstract of an article published in Cancer Research, "The use of immunomodulating gene therapy in the treatment of malignant disease is under intensive investigation. In this study, we examined the potential of melanoma-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) to inhibit melanoma progression in a murine model. The HFH18 murine melanoma cell line was transfected with the murine GM-CSF gene in a SV40 expression vector that resulted in melanoma clones that produced varying amounts of GM-CSF. Syngeneic mice inoculated s.c. with HFH18 parental melanoma cells or HFH18 cells transfected with the GM-CSF gene in the noncoding 3'-5' orientation...
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Source: Gene Therapy Weekly (1996-06-03)
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