Gynecologic Cancers
"The Role of the HER-2/neu Oncogene in Gynecologic Cancers."
Published in Gene Therapy Weekly, June 10th, 1996
According to the authors' abstract of an article published in Journal of the Society for Gynecologic Investigation, "Objective: The HER-2/neu proto-oncogene (also known as c-erbB2, neu, and HER2) encodes a 185-kDa transmembrane glycoprotein with intrinsic tyrosine kinase activity that resembles the receptor for epidermal growth factor. Aberrant HER-2/neu protein overexpression occurs in human gynecologic adenocarcinomas, including those of the ovary, endometrium, breast, fallopian tube, and cervix, and is secondary to gene amplification and/or overexpression of the p185(HER2) protein. Methods: A Medline literature search revealed numerous studies on HER-2/neu and tumor...
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Source: Gene Therapy Weekly (1996-06-10)
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