"Protease-Defective gp120-Containing HIV-1 Particles Induce Apoptosis More Efficiently than Wild-Type Virus in Mitogen-Stimulated Healthy Donor-Derived Peripheral Blood Cells."

According to an abstract submitted by the authors to the 96th General Meeting of the American Society for Microbiology, held May 19-23, 1996, in New Orleans, Louisiana, "Apoptosis and syncytia formation are two mechanisms whereby HIV impairs uninfected CD4⁺ T-cell function, leading to pathogenesis and AIDS. Previously, we showed that gp120-containing, HIV protease-deficient particles (L-2) generated syncytia in uninfected CD4⁺ cultured T-cells. Here, we present evidence that such L-2 particles can induce apoptosis in about 50% of mitogen-stimulated T-cells derived from healthy donor peripheral blood mononuclear cells (PBMC-T). Activation with PHA or Con A after...

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