"Antisense Inhibition of Vitamin D Receptor Expression Induces Apoptosis in Monoblastoid U937 Cells."

According to the authors' abstract of an article published in Journal of Immunology, "The active vitamin D-3 metabolite 1,25-dihydroxycholecalciferol (1,25(OH)(2)D-3) acts as an antiproliferative and differentiating agent for the monoblastoid cell line U937 and as an important immunologic mediator implicated particularly in the function of cells belonging to the monocyte/macrophage lineage. These effects are controlled by the vitamin D receptor (VDR), a member of the steroid hormone receptor family. The objective of this study was to develop U937 transfectants expressing antisense VDR mRNA, and to use these to examine the role of 1,25(OH)(2)D-3-VDR interaction in this lineage. A 2-kb...

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