Published in Gene Therapy Weekly, July 29th, 1996
Gene therapy vectors range from replication incompetent viruses to DNA formulated with various delivery vehicles. Direct delivery of DNA alone has yielded successful gene transfer in isolated applications (J.A. Wolf et al., Science, 1990;247:1465-68); however, the majority of nonviral DNA transfer modalities require the assistance of a delivery vehicle.
Cationic lipids, liposomes, poly-L-lysing conjugates and polymers are among some of the gene delivery vehicles used in the past. Each system has...
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