Cancer Gene Therapy

Immunotherapy Possible with Particle-Mediated Cytokine Gene Transfer

Published in Gene Therapy Weekly, August 5th, 1996

Local cytokine delivery to oral mucosal tissue and epidermis is possible with particle-mediated gene delivery.

Vaccination sites such as the epidermis and oral mucosa have immune effector cells that are unique to their respective anatomic location. Cytokines have been demonstrated to have an immunostimulatory effect on these cells, and as such, may be exploited to enhance vaccine and antitumor responses.

Cancer immunotherapy has been shown successful against immunogenic and nonimmunogenic tumors. Many of these protocols rely on systemic cytokine administration to boost the immune response. Unfortunately, systemic cytokine administration at the...

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Source: Gene Therapy Weekly (1996-08-05)

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