Published in Gene Therapy Weekly, August 5th, 1996
IGFs are important mitogens in several cancers and enhance tumor formation, growth and metastasis. Several recent studies have established the roles of IGF-I and IGF-Ir by utilizing antisense technology to inhibit their expression (M. Resnicoff et al., Cancer Res., 1994;54:2218-22).
Choon-Taek Lee et al. constructed an adenoviral vector expressing antisense IGF-Ir (Ad-Igf-Ir/as) and designed experiments to determine its effectiveness in the reduction of IGF-Ir expression and its effectiveness as...
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