Published in Gene Therapy Weekly, August 5th, 1996
The ability to insert transgenes into pluripotent hematopoietic stem cells could result in the ex vivo gene therapy treatment of several different diseases and disorders. Previous research with retroviral vectors has shown that hematopoietic cells can be transfected and will express the newly inserted gene product.
However, for efficient transduction with retroviral vectors, the stem cells must be stimulated into a state of division. Unfortunately, the cytokine-induced prestimulation results in the loss of the self-renewal capacity and also commits the...
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