Factor IX Clotting Activity Enhanced by Genetic Replacements

Building on previous research, J.-Y. Chang and colleagues from the University of North Carolina, submitted updates on their research concerning the development of clotting factors for hemophilia at the 22nd International Congress of the World Federation of Hemophilia, held June 23-28, 1996, in Dublin, Ireland (abstract "Enhancement of the Factor IX Clotting Activity By Replacing the First Epidermal Growth Factor-Like Domain with that of Factor VII").

In their previous work (Chang et al., Biochemistry 1995;34:12227), the authors used molecular biological techniques to make a chimeric...

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