Cancer Gene Therapy

Distant Bystander Effect Exhibited in HSV-tk Suicide Gene Therapy

Published in Gene Therapy Weekly, August 26th, 1996

In addition to a local bystander effect, suicide gene therapy with the transfection of herpes simplex virus thymidine kinase (HSV-tk) gene also produces a distant bystander effect.

Head and neck squamous cell carcinoma has a survival rate of approximately 50 percent. In spite of advances in cancer therapeutics, this rate has not changed in over 50 years.

In an effort to bring gene therapy for head and neck cancer one step closer to clinical reality, Ohio researchers Keith M. Wilson et al. conducted a study to determine whether the bystander effect demonstrated in vitro for ganciclovir (GCV)-mediated killing of a HSV-tk gene-infected...

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Source: Gene Therapy Weekly (1996-08-26)

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