Conference Coverage (Vancouver AIDS Conference)

Cell Receptor for Anti-HIV Chemokines Identified

Published in Gene Therapy Weekly, September 9th, 1996

The recently described (beta)-chemokines inhibit HIV by binding to the C-C CKR-5 co-receptor on T cells.

Identification of co-receptors necessary for HIV infection of CD4⁺ T cells opens up new targets for vaccines.

AIDS researcher Paolo Lusso and colleagues recently reported that several cellular factors known as (beta)-chemokines - RANTES, MIP-1(alpha), and MIP-1(beta) - have potent anti-HIV activity.

"This was an extremely important paper that will influence research for years to come," said John P. Moore of The Aaron Diamond AIDS Research Center, New York City.

Moore reported the discovery that...

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Source: Gene Therapy Weekly (1996-09-09)

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