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Conference Coverage (Vancouver AIDS Conference)

Naked DNA + Vitamin D3 = Mucosal Anti-HIV Response

Published in Gene Therapy Weekly, September 9th, 1996

When administered with vitamin D3, a DNA vaccine encoding an HIV antigen induces what appears to be a common mucosal immune response in mice.

The immunization protocol apparently is suitable for human testing.

"This should be well tolerated in humans," said William M. Mitchell of Vanderbilt University, Nashville, Tennessee. "This is an active biologic metabolite of vitamin D3. It is currently used in clinical medicine and is an FDA-approved drug."

Mitchell described the mouse studies in a presentation to the XI International Conference on AIDS, held July 7-12, 1996, in Vancouver, British Columbia, Canada.

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